Search results for " gluten-free diet"

showing 5 items of 5 documents

A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease

2007

BACKGROUND: Treatment of celiac disease (CD) is based on the avoidance of gluten-containing food. However, it is not known whether trace amounts of gluten are harmful to treated patients. OBJECTIVE: The objective was to establish the safety threshold of prolonged exposure to trace amounts of gluten (ie, contaminating gluten). DESIGN: This was a multicenter, double-blind, placebo-controlled, randomized trial in 49 adults with biopsy-proven CD who were being treated with a gluten-free diet (GFD) for > or =2 y. The background daily gluten intake was maintained at < 5 mg. After a baseline evaluation (t0), patients were assigned to ingest daily for 90 d a capsule containing 0, 10, or 50 mg glute…

AdultMaleGluten free diet Celiac Diseasemedicine.medical_specialtyGlutensPlacebo-controlled studyMedicine (miscellaneous)gastroenterologyDiseasedigestive systemGastroenterologyCoeliac diseaselaw.inventionRandomized controlled trialDouble-Blind Methodgluten-free dietlawInternal medicineImmunopathologyIntestine SmallMedicineHumansgluten toxicitysmall-intestinal morphometryLymphocyte CountProspective StudiesIntestinal MucosaProspective cohort studyAutoantibodiesceliac disease; gastroenterology; gluten threshold in gluten-free food; gluten threshold in gluten-free food.; gluten toxicity; gluten-free diet; small-intestinal morphometrychemistry.chemical_classificationNutrition and DieteticsDose-Response Relationship Drugbusiness.industrynutritional and metabolic diseasesMiddle Agedmedicine.diseaseGlutendigestive system diseasesgluten threshold in gluten-free foodchemistryToxicityFemalebusinessceliac disease
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Unexplained Elevated Serum Pancreatic Enzymes: A Reason to Suspect Celiac Disease

2006

BACKGROUND & AIMS: The frequency of elevated serum pancreatic enzymes in patients with celiac disease (CD) is unknown. The aim of this study was to evaluate the serum levels of pancreatic enzymes in CD patients. METHODS: Serum pancreatic isoamylase and lipase levels were assayed in 90 adult and 112 pediatric consecutive CD patients at diagnosis and after 12 months of gluten-free diet (GFD). Serum elastase and trypsin levels were assayed in a subgroup of adult CD patients. Pancreatic ultrasonography was also performed. RESULTS: Twenty-six adult (29%) and 29 pediatric (26%) CD patients exhibited elevated values of serum pancreatic amylase and/or lipase; trypsin was elevated in 69% and elastas…

AdultMalemedicine.medical_specialtyAbdominal painSettore MED/09 - Medicina InternaPancreatic diseaseAdolescentGlutensAsymptomaticInternal medicineDiabetes mellitusGFD gluten-free dietmedicineHumansTrypsinAmylaseLipaseChildPancreatic ElastaseHepatologybiologybusiness.industryElastaseGastroenterologyCase-control studyLipasemedicine.diseasetTGs transglutaminasePancreatic celiacCeliac DiseaseEmA anti-endomysiumEndocrinologyCase-Control StudiesChild PreschoolCD celiac diseaseAmylasesbiology.proteinFemalemedicine.symptomSD standard deviationbusinessIsoamylaseFollow-Up StudiesClinical Gastroenterology and Hepatology
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Anemia in Celiac Disease: Prevalence, Associated Clinical and Laboratory Features, and Persistence after Gluten-Free Diet

2022

Anemia is considered to be the most frequent extra-intestinal manifestation of Celiac Disease (CD). We assessed frequency, severity, morphologic features, and pathogenic factors of anemia in patients of the Sicilian Regional Network of Celiac Disease and attempted to identify putative pre-diet factors influencing anemia persistence. We retrospectively analyzed CD patients admitted to three centers between 2016&ndash;2020. 159 patients entered the study (129 females). More than half (54.7%) had mild-moderate, hypochromic and microcytic anemia, associated with below normal total serum iron and ferritin, indicative of iron deficiency anemia (IDA). One year after diagnosis, 134 patients were fo…

Celiac Disease; anemia; iron deficiency; gluten-free dietMedicine (miscellaneous)Celiac Disease anemia gluten-free diet iron deficiency
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Coeliac disease: Oral ulcer prevalence, assessment of risk and association with gluten-free diet in children.

2008

Aims. Oral mucosal lesions may be markers of chronic gastrointestinal disorders, such as those causing malabsorption. Our objectives were to assess the prevalence of recurrent oral aphthous-like ulcers in coeliac disease patients living in the Mediterranean area, and to evaluate the impact of a gluten-free diet. Methods. A test group of 269 patients (age range 3-17 years) with coeliac disease confirmed both serologically and histologically was compared with a control group of 575 otherwise clinically healthy subjects for the presence, or a positive history of aphthous-like ulcers. Coeliac disease patients with aphthous-like ulcers were re-evaluated 1-year after starting a gluten-free diet. …

Malemedicine.medical_specialtyMalabsorptionSettore MED/09 - Medicina InternaAdolescentGlutensComorbidityRisk AssessmentGastroenterologyCoeliac diseasegluten-free dietchildrenRecurrenceInternal medicineEpidemiologyPrevalencemedicineHumansChildCoeliac disease; oral ulcer; gluten-free diet; childrenHepatologyCoeliac diseasebusiness.industryGastroenterologyCase-control studynutritional and metabolic diseasesOdds ratiomedicine.diseaseComorbiditydigestive system diseasesoral ulcerCeliac Diseasestomatognathic diseasesTreatment OutcomeItalyCase-Control StudiesChild Preschoolaphthous ulcerFemaleGluten freebusiness
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Suspected Nonceliac Gluten Sensitivity Confirmed in Few Patients After Gluten Challenge in Double-Blind, Placebo-Controlled Trials

2017

A double-blind, placebo-controlled, gluten challenge has been proposed to confirm a diagnosis of non-celiac gluten sensitivity (NCGS) in patients without celiac disease who respond to a gluten-free diet. To determine the accuracy of this approach, we analyzed data from 10 double-blind, placebo-controlled, gluten challenge trials, comprising 1312 adults. The studies varied in the duration of the challenge (ranging from 1 day to 6 weeks), daily doses for the gluten challenge (ranging from 2 g to 52 g; 3 studies administered less than 8 g/day), and composition of the placebo (gluten-free products, xylose, whey protein, rice, or corn starch containing fermentable carbohydrates). Most of the stu…

medicine.medical_specialtyGlutensGluten sensitivityPlacebodigestive systemGastroenterologyDouble blind03 medical and health sciences0302 clinical medicinegluten-free dietInternal medicineMedicineHumansIn patient030212 general & internal medicineFood scienceceliac disease; gluten-free diet; irritable bowel syndrome; wheat allergyIrritable bowel syndromechemistry.chemical_classificationirritable bowel syndromeHepatologybusiness.industryDiagnostic Tests RoutineGastroenterologynutritional and metabolic diseasesmedicine.diseaseGlutendigestive system diseaseswheat allergychemistry030211 gastroenterology & hepatologyControlled Clinical Trials as TopicFODMAPbusinessWheat allergyceliac diseaseFood Hypersensitivity
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